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Research Insterest

The Tu lab studies grasses to decipher transcriptional regulation underlying C4 photosynthesis.Combining current high-throughput sequencing (e.g. ChIP-seq, ChIP-exo, ATAC-seq, Hi-C,ChIA-PET and RNA-seq) and single-cell multiomics techniques, the Tu lab explores how the genome non-coding regions determine cell fate and achieve precision temporal and spatial regulation of gene expression.

By understanding how the transcriptional regulatory network fine-tune gene expression, we aim to untangle the complexity of the regulatory processes that underline the evolution and differentiation of photosynthetic systems. Expanding the research from the following two aspects:

1. Epigenetic regulation
Chromatin openness and three-dimensional structure, histone post-translational modifications, DNA methylation, etc.

2. Genetic regulation
Regulatory network construction of transcription factors, co-binding, binding footprints, etc.